Impaired Duodenal Palmitoylethanolamide Release Underlies Acid-Induced Mast Cell Activation in Functional Dyspepsia

Authors: Giovanni Sarnelli, Marcella Pesce, Luisa Seguella, Jie Lu, Eleonora Efficie, Jan Tack, Fatima, Domenica Elisa De Palma, Alessandra D’Alessandro, Giuseppe Esposito

Institutions:

• Department of Clinical Medicine and Surgery, Naples, Italy
• Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
• Department of Human Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang City, Liaoning, China
• Translational Research Center for Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium
• CEINGE-Biotecnologie Avanzate s.c.a rl, Department of Molecular Medicine and Medical Biotechnologies, Naples, Italy

Date: October 2020

Publication: Cellular and Molecular Gastroenterology and Hepatology Journal

Full paper: https://www.cmghjournal.org/article/S2352-345X(20)30161-2/fulltext

Abstract:

Acid hypersensitivity is claimed to be a symptomatic trigger in functional dyspepsia (FD); however, the neuroimmune pathway(s) and the mediators involved in this process have not been investigated systematically. Palmitoylethanolamide (PEA) is an endogenous compound, able to modulate nociception and inflammation, but its role in FD has never been assessed.